Cryptococcal Meningitis in Young, Immunocompetent Patients: A Single Center Retrospective Case Series and Review of the Literature
نویسندگان
چکیده
Abstract Background Cryptococcal meningitis is an uncommon but serious infection with a high mortality and morbidity. Classically described in immunocompromised patients, including those solid organ transplants or HIV/AIDS, cryptococcosis has also been reported young otherwise healthy albeit rarely. Methods We retrospectively searched for all cases of cryptococcal (≤50 years) previously patients no known immunocompromising conditions from January 2015 to 2022 at Indiana University Health (IU Health). Additionally, PubMed literature review was performed the keywords “cryptococcal meningitis” “immunocompetent” 1988 2022. Clinical courses, outcomes treatment regimens were evaluated. Results identified 4 local ≤50 years. Three due Cryptococcus neoformans one experiencing post-infectious inflammatory response syndrome (PIIRS). The search 51 additional 32 (63%) being caused by 8 (17%) gattii. Of cases, only two resulted death directly cryptococcosis. Fifteen (29%) had PIIRS steroid documented 11 15. Antifungal induction duration varied predominately consisted amphotericin flucytosine mean 5.0 weeks. Conclusions young, likely under-recognized. (akin IRIS observed HIV/AIDS) prolonged recovery should be concern. Determining risks factors these remains elusive.
منابع مشابه
Case Report Cryptococcal Meningitis in an Immunocompetent Child: a Case Report and Literature Review
An immunocompetent 5 year-old girl presented with pyrexia of unknown origin associated with headache. Initial investigations showed leukocytosis and an increased erythrocyte sedimentation rate. A Widal-Weil Felix test, blood film for malarial parasites, mycoplasma IgM antibody, cultures from blood and urine, full blood picture, Mantoux test, and chest x-ray were all negative. A lumbar puncture ...
متن کاملSecondary pulmonary alveolar proteinosis: a single-center retrospective study (a case series and literature review)
BACKGROUND Secondary pulmonary alveolar proteinosis (sPAP) is an extremely rare disease. The clinical features of sPAP patients remain to be summarizeds. METHODS Patients pathologically diagnosed with PAP and with negative results for anti-granulocyte macrophage colony stimulating factor (GM-CSF) autoantibodies from Peking Union Medical College Hospital between January 2000 and July 2016 were...
متن کاملCryptococcal meningitis in an immunocompetent patient: a case report and review of the literatures
Cryptococcal meningitis is an opportunistic infection in immunosuppressed hosts with high morbidity and mortality. Once suffering from cryptococcal meningitis, immunocompetent patients are more likely to achieve poor outcome, because of the powerful immune response. Here we present a case of cryptococcal meningitis occurring in an immunocompetent host with no definite underlying diseases and no...
متن کاملGlaucoma Surgery in Pregnancy: A Case Series and Literature Review
AbstractGlaucoma management in pregnant patients is a real challenge, especially when the glaucoma is not controlled with medications. We report the results of 6 incisional glaucoma surgeries for the management of medically uncontrolled glaucoma patients during pregnancy. This retrospective, case series was conducted on the 6 eyes of 3pregnant patients with uncontrolled glaucoma using maximum t...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Open Forum Infectious Diseases
سال: 2023
ISSN: ['2328-8957']
DOI: https://doi.org/10.1093/ofid/ofad420